Observational Study Summary

Diseases of bone associated with ageing reduce bone mass, bone strength and joint integrity. Current non-surgical approaches are limited to pharmaceutical agents that are not disease modifying and have poor patient tolerability due to side effect profiles. Developing a fundamental understanding of cellular bone homeostasis, including how key cell types affect tissue health, and offering novel therapeutic targets for prevention of bone disease is therefore essential. This is the focus of OSTEOMICS.
A number of factors have been linked to increased risk of bone disease, including genetic predisposition, diet, smoking, ageing, autoimmune disorders and endocrine disorders. In our study, we will recruit patients undergoing elective and non-elective orthopaedic surgery and obtain surgical bone waste for analysis. This will capture a cohort of patients with bone disorders in addition to patients without overt clinical bone disease. We will study the relationship between the molecular biology of bone cells, bone structure, genetics (DNA) and environmental factors with the aim of identifying and validating novel therapeutic targets.
We will leverage modern single cell technologies to understand the diversity of cell types found in bone. These technologies have now led to the characterisation of virtually every tissue in the body, however bone and bone-adjacent tissues are massively underrepresented due to the anatomical location and underlying technical challenges. Early protocols to demineralise bone and perform single cell profiling have now been developed. We will systematically scale up these efforts to observe how genetic variation at the population level leads to alterations in bone structure and quality.
Over the coming years, we will generate data to comprehensively characterise bone across health and disease, use machine learning to drive analysis, and experimentally validate hypotheses - which will ultimately contribute to developing the next generation of therapeutic agents.

Updates and announcements will be made through this website.

Contact points:

  • General enquiries: osteomics@relationrx.com

  • Data protection officer: dataprotectionofficer@relationrx.com (Dr. Jake P. Taylor-King)

Meet the Team

  • Mr. Raghbir Khakha

    Consultant Trauma and Orthopaedic Surgeon, and Principal Investigator (HSSH)

    Mr Khakha’s NHS practice is based in a Central London Teaching Hospital at Guy’s and St Thomas’. He has been in consultant practice since 2017 with a passion for joint preservation techniques, having learnt from leading experts from around the world utilising innovative and cutting edge techniques.

    Mr Khakha regularly publishes in peer-reviewed journals, having co-authored over 25 publications, book chapters and consensus documents used internationally. He is currently sits on the osteotomy committee for the European Society of Sports Traumatology, Knee Surgery and Arthroscopy. He is the deputy training programme director for the Orthopaedic Training Programme in South London.

  • Mr. Akash Patel

    Mr. Akash Patel

    Consultant Trauma and Orthopaedic Surgeon, and Principal Investigator (Royal Free Hospital, Chase Farm Hospital).

    Mr Akash Patel is a consultant trauma and orthopaedic surgeon operating within the Royal Free London NHS Foundation Trust, with subspeciality interest in Hip and Knee disorders: joint replacements, arthroscopy (keyhole surgery), sports injuries, and trauma. He is also an Associate Professor at University College London.

    Mr Patel graduated from University College London (2005) and was selected to undertake orthopaedic training on the Imperial Northwest London rotation. He undertook specialist UK hip/knee fellowships at Royal Berkshire and Royal Free London Hospitals, with further training including: Royal North Shore Hospital (Australia), ESSKA Knee Fellowship (Germany, France, Holland), Trauma Travelling Fellowship (South Africa) and International Healthcare Leadership Programme (Switzerland). In addition, Mr Patel has completed a BSc (UCL) and MSc (Evidence Based Orthopaedics – Warwick University). He has published research extensively, and presented nationally/internationally, winning numerous prizes.

  • Dr. Jake P. Taylor-King

    Chief Investigator and Data Protection Officer

    Jake Taylor-King is the co-founder and Chief Innovation Officer at Relation Therapeutics, where his role looks across strategy, science, and technology. At graduate school, Jake was a mathematician at Oxford with broad interests including biomedical topics including bone formation and histology analysis. A postdoc at the ETH Zürich (dept. biology) then kindled interest in emerging technologies including single-cell genomics and CRISPR.

  • Amaia Vilas–Zornoza

    Relation Therapeutics Principal Scientist

    Amaia is a team leader with 16 years of experience in drug discovery and the application of cutting-edge technologies. Amaia’s academic journey began at the University of Navarra, where she pursued a Ph.D. and a postdoctoral fellowship, focusing on the development of novel drug treatments for leukemia. During this period, Amaia conducted extensive research both in vitro and in vivo specializing in the development of new compounds to leukemia treatments. She later became Principal Researcher at CIMA, Pamplona, focusing on Next-Generation Sequencing, especially in single-cell genomics and spatial transcriptomics across a wide range of tissues and conditions, including bone, bone marrow, cardiac pathologies, neuro diseases and hepatocarcinoma, among others. Her involvement in several projects that are integral parts of the Human Cell Atlas (HCA), underscore her commitment to advancing our understanding of human biology and treating complex diseases.

  • Dr. Rosie Rodriguez

    Relation Therapeutics SVP of Growth and Operations (and acting sponsor representative).

    Rosie brings over 18 years of successful Research and Development experience in Pharmaceuticals and Life Sciences. She is a senior executive accomplished in Clinical Development, Alliance and Portfolio Management and Business Strategy. Rosie holds a PhD from The Institute of Cancer Research (CRUK).

  • Dr. Lorenzo Ramos-Mucci

    Relation Therapeutics Senior Scientist

    Lorenzo is researcher with expertise in single-cell genomics and musculoskeletal biology. Previously Lorenzo was a postdoc at Oxford University where he conducted numerous single-cell and spatial transcriptomics experiments and analyses as part of the Tendon Seed Atlas. He also completed a PhD at the University of Liverpool, an MSc at the University of Twente and a BSc at Yale University.

  • Dr. Rebecca McIntyre

    Relation Therapeutics VP of Experimental Science.

    Rebecca comes to Relation from the Human Genetics Programme of The Sanger Institute, where she served as Principal Staff Scientist and will continue to maintain a collaborative role.

    Rebecca is a functional geneticist and team leader with 20 years experience in oncology, inflammation and neuroscience areas. Rebecca has led large-scale data generation efforts using single cell genomics and CRISPR/Cas technologies to identify novel therapeutic targets for genetic diseases.

  • Mr Yegappan Kalairajah

    Mr Yegappan Kalairajah

    Consultant Trauma and Orthopaedic Surgeon, and Principle Investigator (Luton & Dunstable University Hospital)

    Yega Kalairajah graduated from Cambridge University, and Guy’s and St. Thomas’ Hospital in London, in 1995. He carried out his basic surgical training in South East London (King’s) and subsequently went on to do his orthopaedic training in the South West London Region (St. George’s). Mr Kalairajah was appointed as Consultant Orthopaedic Surgeon at the Luton and Dunstable University Hospital (L&D) in 2007, with the aim of forming the hip and knee unit within the trust. The L&D now provides all cutting-edge treatments available for hip and knee disorders to the region and further afield.

  • Mr Victor Babu

    Consultant Trauma and Orthopaedic Surgeon, and Principle Investigator (West Middlesex University Hospital)

    Mr Babu completed his training at Christian Medical College, Vellore, India and Royal College of Surgeons, Edinburgh. Until 2002, he was on North-West Thames rotation in Orthopaedics & Trauma. He has been in post as Consultant Surgeon Orthopaedics and Trauma at the West Middlesex University Hospital since July 2002.